MUDr. Jan Mičan

2026

• Accessible biocatalyst development by rapid in vitro semi-rational engineering (RISE) of enzymes

  TELEK Andras GAJAK Viktor Zsolt DARGO Gergo MIČAN Jan BEDNÁŘ David VERTESSY Beata G. TASNADI Gabor

  Article in Periodical

  iScience, year: 2026, volume: 29, edition: 1, DOI

2024

• Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes

  MIČAN Jan JARADAT Da 'san M. M. LIU Weidong WEBER Gert MAZURENKO Stanislav BORNSCHEUER Uwe T. DAMBORSKÝ Jiří WEI Ren BEDNÁŘ David

  Article in Periodical

  Applied Catalysis B: Environment and Energy, year: 2024, volume: 342, edition: March 2024, DOI

2023

• Identification, characterization, and engineering of glycosylation in thrombolytics

  TOUL Martin SLONKOVÁ Veronika MIČAN Jan URMINSKÝ Adam Paulin TOMKOVA Maria SEDLÁK Erik BEDNÁŘ David DAMBORSKÝ Jiří HERNYCHOVÁ Lenka PROKOP Zbyněk

  Article in Periodical

  Biotechnology Advances, year: 2023, volume: 66, edition: September 2023, DOI

2022

• Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

  NIKITIN Dmitri MIČAN Jan TOUL Martin BEDNÁŘ David PEŠKOVÁ Michaela KITTOVÁ Patrícia THALEROVÁ Sandra VÍTEČEK Jan DAMBORSKÝ Jiří MIKULÍK Robert FLEISHMAN Sarel J. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2022, volume: 20, edition: May 2022, DOI

• Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase

  TOUL Martin MIČAN Jan SLONKOVÁ Veronika NIKITIN Dmitri MAREK Martin BEDNÁŘ David DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  Stroke, year: 2022, volume: 53, edition: 10, DOI

• IMPACT OF ADMINISTRATION METHOD OF THROMBOLYTICS ON THEIR THROMBOLYTIC EFFECTS

  DAVUT AKSU Ahmet HLOŽKOVÁ Jana SCHEER Peter BRHELOVÁ Eliška MIČAN Jan TOUL Martin DAMBORSKÝ Jiří KAŠPÁREK Petr DOLAŽALOVÁ Jana MIKULÍK Robert

  Appeared in Conference without Proceedings

  Year: 2022, type: Appeared in Conference without Proceedings

• Mechanism-Based Design of Efficient PET Hydrolases

  WEI Ren VON HAUGWIT Gerlis PFAFF Lara MIČAN Jan BADENHORST Christoffel P. S. LIU Weidong WEBER Gert AUSTIN Harry P. BEDNÁŘ David DAMBORSKÝ Jiří BORNSCHEUER Uwe T.

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 6, DOI

• Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase

  PFAFF Lara GAO Jian LI Zhishuai JAECKERING Anna WEBER Gert MIČAN Jan CHEN Yinping DONG Weiliang HAN Xu FEILER Christian G. AO Yu-Fei BADENHORST Christoffel P. S. BEDNÁŘ David PALM Gottfried J. LAMMERS Michael DAMBORSKÝ Jiří STRODEL Birgit LIU Weidong BORNSCHEUER Uwe T. WEI Ren

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 15, DOI

• Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization

  VON HAUGWITZ Gerlis HAN Xu PFAFF Lara LI Qian WEI Hongli GAO Jian METHLING Karen AO Yufei BRACK Yannik MIČAN Jan FEILER Christian G WEISS Manfred S BEDNÁŘ David PALM Gottfried J. LALK Michael LAMMERS Michael DAMBORSKÝ Jiří WEBER Gert LIU Weidong BORNSCHEUER Uwe T. WEI Ren

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 24, DOI

2021

• Development and Testing of Thrombolytics in Stroke

  NIKITIN Dmitri CHOI Seungbum MIČAN Jan TOUL Martin RYU Wi-Sun DAMBORSKÝ Jiří MIKULÍK Robert KIM Dong-Eog

  Article in Periodical

  JOURNAL OF STROKE, year: 2021, volume: 23, edition: 1, DOI