Mgr. Helena Peschelová, Ph.D.

2022

• Genome-wide Screening Optimizations and High-throughput Compound Screening to Identify Novel Treatment Options in Venetoclax-resistant AML

  LODHI Yusuf LADUNGOVÁ Adriana BUŠA Daniel PESCHELOVÁ Helena ČULEN Martin ŠMÍDA Michal

  Conference abstract

  Year: 2022, type: Conference abstract

• Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells

  DAVE Zankruti VONDÁLOVÁ BLANÁŘOVÁ Olga ČADA Štěpán JANOVSKÁ Pavlína ZEZULA Nikodém BĚHAL Martin HANÁKOVÁ Kateřina GANJI Sri Ranjani KREJČÍ Pavel GÖMÖRYOVÁ Kristína PESCHELOVÁ Helena ŠMÍDA Michal ZDRÁHAL Zbyněk PAVLOVÁ Šárka KOTAŠKOVÁ Jana POSPÍŠILOVÁ Šárka BRYJA Vítězslav

  Article in Periodical

  Frontiers in Cell and Developmental Biology, year: 2022, volume: 10, edition: February 2022, DOI

• Prediction of novel treatment options for CLL and AML cells based on drug repurposing.

  LADUNGOVÁ Adriana BUŠA Daniel PESCHELOVÁ Helena LODHI Yusuf ČULEN Martin ŠMÍDA Michal

  Conference abstract

  Year: 2022, type: Conference abstract

2021

• CD19 promoter hypermethylation as means of antigen-negative escape to CART-19 therapy.

  DOSTÁLOVÁ Lenka LEDEREROVÁ Aneta KOZLOVÁ Veronika PESCHELOVÁ Helena LADUNGOVÁ Adriana MANČÍKOVÁ Veronika ŠMÍDA Michal

  Conference abstract

  Year: 2021, type: Conference abstract

• Drug repositioning in genetically defined CLL cases reveals a potentional novel therapeutic use for approved drugs.

  LADUNGOVÁ Adriana PESCHELOVÁ Helena KOZLOVÁ Veronika ŠMÍDA Michal

  Conference abstract

  Year: 2021, type: Conference abstract

• Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro

  LEDEREROVÁ Aneta DOSTÁLOVÁ Lenka KOZLOVÁ Veronika PESCHELOVÁ Helena LADUNGOVÁ Adriana ČULEN Martin LOJA Tomáš VERNER Jan POSPÍŠILOVÁ Šárka ŠMÍDA Michal MANČÍKOVÁ Veronika

  Article in Periodical

  Journal for ImmunoTherapy of Cancer, year: 2021, volume: 9, edition: 8, DOI

• In vivo antigen-negative escape to CART-19 caused by CD19 promotor hypermethylation.

  DOSTÁLOVÁ Lenka LEDEREROVÁ Aneta KOZLOVÁ Veronika PESCHELOVÁ Helena LADUNGOVÁ Adriana LOJA Tomáš VERNER Jan POSPÍŠILOVÁ Šárka MANČÍKOVÁ Veronika ŠMÍDA Michal

  Conference abstract

  Year: 2021, type: Conference abstract

2020

• CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

  KOZLOVÁ Veronika LEDEREROVÁ Aneta LADUNGOVÁ Adriana PESCHELOVÁ Helena JANOVSKÁ Pavlína SLUSARCZYK A. DOMAGALA J. KOPČIL Pavel VAKULOVÁ Viera OPPELT Jan BRYJA Vítězslav DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Article in Periodical

  Plos one, year: 2020, volume: 15, edition: 3, DOI

• Combination of epigenetic drug screen and CRISPR knockout screen revealed involvement of aurora kinases and Cullin 3 in CD20 regulation

  LEDEREROVÁ Aneta KOZLOVÁ Veronika MANČÍKOVÁ Veronika PESCHELOVÁ Helena PERSSON J. SCHMIERER B. DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka ŠMÍDA Michal

  Conference abstract

  Year: 2020, type: Conference abstract

• CRISPR/CAS9 technology: a useful tool in the study of chronic lymphocytic leukemia

  PESCHELOVÁ Helena KOZLOVÁ Veronika MANČÍKOVÁ Veronika LADUNGOVÁ Adriana HEJRET Václav ŠMÍDA Michal

  Conference abstract

  Year: 2020, type: Conference abstract